General Organic Chemistry II

Required reading: Solomons, Organic Chemistry, 13th edition, via WileyPLUS. Chapter coverage: 10–20 and 22–24. Companion listed: T. W. Graham Solomons, Craig B. Fryhle and Scott A. Snyder, Organic Chemistry Student Study Guide and Solutions Manual, 13th edition. Module notes govern content coverage; assigned readings may add material.

Required: Conjugated Systems Conjugated Systems - The Diels Alder Reaction - Part 1. Conjugated Systems - The Diels Alder Reaction - Part 2.

Required: Aromatic Molecules - 1 Required Reading – Solomons - Chapter 14/15

Required: Aromatic Molecules - Aromaticity, Hückel Theory. Aromatic Molecules - Resonance Aromatic Molecules - Reactivity - Electrophilic Aromatic Substitution (EAS), Friedel- Crafts Acylation and Alkylation.

Required: Aromatic Molecules - 2 Required Reading – Solomons - Chapter 14/15

Required: Aromatic Molecules - Reactivity - Directing Groups and Selectivity. Aromatic Molecules - Reactivity Aromatic Molecules - Reactivity - Synthetic Strategies - Protecting Groups, Functional Group Interconversion (FGI).

Required: Alcohols and Ethers Required Reading – Solomons - Chapter 11

Required: Alcohols and Ethers - Nomenclature, Structure, Reactivity. Alcohols and Ethers - Synthesis and Protection. Alcohols and Ethers - Synthesis via Epoxidation.

Required: Alcohols and the Carbonyl Group Required Reading – Solomons - Chapter 12

Required: Alcohols and the Carbonyl Group - Introduction to the Carbonyl Group. Alcohols and the Carbonyl Group - Addition to the Carbonyl Group (Grignard Reagents, Organolithiums). Alcohols and the Carbonyl Group - Reduction, Oxidation and Protection.

Required: Organic Radicals Required Reading – Solomons - Chapter 10

Required: Radicals - Stability, Structure and Generation. Radicals - Mechanism and Selectivity. Radicals - Application, Examples, polymerisation

Required: Aldehydes and ketones Required Reading – Solomons - Chapter 16

Required: Synthesis of and reactions of, including acetal formation, amine additions, HCN addition, Wittig reaction.

Required: Nomenclature, physical properties, synthesis and reactions. Nucleophilic addition- elimination reaction at the acyl carbon.

Required: Aldehydes and ketones, reactions of α-C-H. Required Reading – Solomons - Chapter 18.1-18.7

Required: Keto and enol tautomers. Malonic and acetoacetic ester synthesis. Lithium enolates.

Required: Dicarbonyls, synthesis and reactions. Required Reading – Solomons - Chapter 19.1 –19.6

Required: Claisen condensation, crossed aldol condensation, cyclization via aldol condensation.

Required: Amines. Required Reading – Solomons - Chapter 20.1-20.5

Required: Properties and synthesis.

Required: Carbohydrates. Required Reading – Solomons - Chapter 22

Required: Monosaccharides, properties, and reactions. Disaccharides and polysaccharides.

Required: Lipids and fats, steroids. Required Reading – Solomons - Chapter 23

Required: Properties, reactions, and biosynthesis of lipids, terpenoids, and steroids.

Required: Amino acids and peptides. Required Reading – Solomons - Chapter 24

Required: Protecting groups. Peptide bond synthesis. Solid phase synthesis of peptides.

Required: Friendly Advice:

Required: 2) The module notes take precedent over the textbook for content coverage unless specified otherwise (assigned readings that are not in notes etc). You are also responsible for the material covered in module notes which may not be covered in the textbook, unless specified. You SHOULD be using the textbook in addition to your module notes to ensure you have a full understanding of topics.

Required: Textbooks/Readings

Required: Organic Chemistry, Solomons and Fryhle 13th edition.