CHEM 422

Synthetic Organic Chemistry

3.00 units · Undergraduate

Winter 2025 · ENCH 422

Topics

Efficiency in synthesis
Stereoselectivity/chirality in synthesis
Electrophilic aromatic substitution
Alkene/alkyne synthesis including Wittig, Horner-Wadsworth-Emmons and metathesis
5 Total Synthesis of Complex Molecules
Organic chemistry
Stereochemistry
Learning
Reaction mechanisms

Listed material: S. Warren, P. Wyatt, Organic Synthesis: The Disconnection Approach, Wiley: N.Y., 2008. (Intermediate).

2022 · ENCH 422

Efficiency in synthesis
Stereoselectivity/chirality in synthesis
Electrophilic aromatic substitution
Alkene/Alkyne synthesis including Wittig, Horner Wadsworth Emmons and metathesis reactions
Total Synthesis of Selected Molecules
Presentation (TBA, tentatively weeks of March 28 – April 8, in class)
Organic chemistry
Stereochemistry

Listed material: Rather than have one required textbook, we will be using several textbooks as reference material and will also be using references from the primary literature.
Listed material: S. Warren, P. Wyatt, Organic Synthesis: The Disconnection Approach, Wiley: N.Y., 2008. (Intermediate) P. Wyatt, S. Warren, Organic Synthesis: Strategy and Control, Wiley: N.Y., 2007. (Intermediate) Carey and Sundberg, Advanced Organic Chemistry, Part B (Intermediate) Smith, M.B.; March, J. March’s Advanced Organic Chemistry, 5th Ed. Wiley-Interscience, NY 2001 (reference) Weeks, D.P. Pushing Electrons, 3rd Ed. Saunders, Fort Worth, 1998. (Elementary) Eliel, E.L.; Wilen, S.H.; Doyle, M.P. Basic Organic Stereochemistry, Wiley: Chichester, 2001 (Advanced) Nicolaou, K.C., Snyder, S.A.; Classics in Total Synthesis II, Wiley-VCH, New York, 2003 (Advanced)

Sources