ENGINEERING DRUG DELIVERY SYSTEMS

Credit Hours: 3 · Undergraduate Upper-Level

This course will focus on the application of innovative engineering approaches to enhance drug efficiency and/or reduce toxicity. Topics of emphasis include, but are not limited to, routes of administration, bioavailability, biodistribution, pharmacokinetics, pharmacodynamics, therapeutic drug windows, patient compliance, immunogenicity, the foreign body reaction, and solubility enhancement. A wide array of device types will be discussed, such as biodegradable microspheres, self-assembled lipid nanoparticles, microneedles, and osmotic pumps. Students will be expected to quantitatively evaluate drug release from complex devices and determine drug distribution and clearance using multi-compartment models. Graduate/Undergraduate Equivalency: BIOE 515 . Mutually Exclusive: Cannot register for BIOE 415 if student has credit for BIOE 515 .