Eukaryotic Gene Regulation

4.0 credits

This advanced course examines mechanisms of chromatin-mediated regulation of the eukaryotic genomes, gene expression, relating molecular structures, dynamic interactions, nuclear processes, 3-D nuclear organization to biological functions. Topics include DNA structures, packaging and higher order chromatin organization in the nucleus, the transcription machinery, eukaryotic chromosome structure and its modifications, epigenetics and functional genomics, dynamics of nuclear processes, nuclear reprogramming, development and applications of genome manipulation technology. Lectures and readings draw heavily on primary literature both classic and most recent.