Cancer Biology

3.0 credits

This course serves as an introduction to concepts and current problems in molecular and cellular biology of cancer with a focus on human disease-relevant models. We will cover: Genetic Basis of Cancer, from classical oncogenes and tumor suppressor genes to current ‘omic analysis of cancer genes, genomes, transcripts and epigenetics, and cancer epidemiology; Cell Biology of Cancer, including alterations in signaling, apoptosis, metabolism, and cancer stem cells in tumor initiation, recurrence and metastasis; and Cell-Cell Interactions in Cancer and the Microenvironment, including the relationship between aging and cancer, hormone signaling, interaction of tumors with the microenvironment, tumor immunology and immunotherapy.