Biochemical Toxicology

4.0 credits

This course covers the principles of toxicology and their applications with emphasis on understanding fundamental mechanisms of toxicant-target interactions at the molecular and cellular levels. Topics covered include: toxicokinetics, biotransformation, transport and elimination, receptor theory and endocrine disruption, oxidative mechanisms and reactive intermediates, genotoxicity, carcinogenesis and epigenetic modifications. These concepts will be related to understanding human health consequences of relevant toxic agents and other stressor exposures in our environment and workplace. Practical application of these concepts will be introduced through examples of exposure assessment studies and environmental epidemiology.