ICP-MS and LC-MS-MS

0.5 credits · Graduate

In this course, students will be taught the theory and practical application of Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) and Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS). Students will cover several key areas of each technique. For LC-MS/MS, this will include electrospray ionization, optimization of ionization and chromatography parameters, fragmentation, quantitation techniques and quality assurance. For ICP-MS, this will include plasma generation, choice of sampler and skimmer cones, liquid sample introduction, calibration strategies and collision/reaction cells. By the end of this course, successful students will be competent in the operation of a commercial ICP-MS and LC-MS/MS instrument and have experience of analytical method development for real-world samples.