Chromatin & Epigenetics

Undergraduate / Graduate

This course presents the dynamic nature of the physiological genome - an exquisitely regulated macromolecular polymer termed chromatin - that gives rise to hundreds of cellular identities, each adaptable to various environmental milieu. Students will explore the mechanisms and determinants that shape distinct chromatin conformations and their influences on gene expression and cell fate. Topics include histone modifications, ATP-dependent chromatin remodeling, DNA methylation, Polycomb, heterochromatin, topologically associating domains, phase transition, and non-coding RNA. Students will apply their knowledge to understand the role of chromatin structure in development (e.g. lineage specification), disease (e.g. cancer) and potential therapeutics (e.g. cellular reprogramming). Students will leave the course with an in-depth knowledge of cutting-edge epigenetic methodologies as well as the ability to critically evaluate primary literature and propose original scientific research.