Chemistry of Enzyme Catalysis

Undergraduate / Graduate

The course will cover fundamental aspects of the physical organic chemistry of enzyme catalysis, with special emphasis on the role of pre-oriented local electric fields in catalysis, and will use case studies based on the primary scientific literature--both classic and current papers. For each class, there will be primary scientific papers assigned that the student will be expected to have studied in depth prior to class, including "reading around" on the same and related topics; suggestions for supplementary reading will be given. Classes will be conducted as discussion sessions; guided by the Instructor--all students will be expected to be prepared to answer questions from the instructor, and to take active part in class discussions. Participation in class will count for a portion of the grade for each student.