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CHM 8304

Advanced Topics in Organic Chemistry

1.5 units

Winter 2014 · Enzyme Kinetics

Topics

  • Enzyme catalysis and energy diagrams
  • Rate laws, molecularity and experimental kinetic analysis
  • Steady-state, saturation and pre-steady-state kinetics
  • Graphical analysis of enzyme kinetics
  • Reversible, slow-binding, tight-binding and irreversible inhibition
  • Optional case studies of chymotrypsin and mechanism-based inhibitors

Readings

  • Modern Physical Organic Chemistry
    Anslyn; Dougherty · Recommended
  • Fundamentals of Enzyme Kinetics
    Cornish-Bowden · Recommended
  • Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Systems
    Segel · Recommended
Winter 2013 · Physical Organic Chemistry

Topics

  • Reaction energy surfaces and transition-state theory
  • Experimental kinetics and complex reactions
  • Isotope and substituent effects
  • Linear free-energy relationships
  • Thermodynamic aspects of catalysis
  • Acid–base and enzyme catalysis

Readings

  • Modern Physical Organic Chemistry
    Anslyn; Dougherty · Recommended
  • Mechanism and Theory in Organic Chemistry
    Lowry; Richardson · Recommended
  • Physical Organic Chemistry
    Isaacs · Recommended
  • The Physical Basis of Organic Chemistry
    Maskill · Recommended
  • Catalysis in Chemistry and Enzymology
    Jencks · Recommended
  • Advanced Organic Chemistry, Part A
    Carey; Sundberg · Recommended
Sources