Precision Cancer Medicine

2 credits · Graduate School

Precision medicine is the tailoring of patient therapy based on pharmacogenetic biomarkers that predict the likelihood of drug response or risk of adverse events, and highlights the importance of foundational science translation in improving patient outcomes. Although precision medicine can be applied to a number of diseases, oncology, arguably, sits at the forefront. Over the last decade, there has been an increase in the understanding of cancer molecular drivers and based on this information, gene mutation-specific inhibitors have been successfully used in the clinic that target only sub-populations of patients with particular tumor genotypes. As a result, there is a need for oncologists to have an appreciation of the fundamental molecular biology underlying the patient's tumor to effectively translate tumor genotype to precision patient care. This course will provide a unique experience in oncology where medical and graduate students work together to explore the molecular drivers of cancer and how that information is translated into targeted cancer therapies. Foundational science topics will include anatomy, physiology, histology, biochemistry, cell biology, genetics, molecular biology, immunology, pathology, radiobiology, and toxicology. Students will explore the concepts of oncogene addiction, acquired resistance to targeted therapy, immunotherapy, tumor heterogeneity, drug discovery, genetic screening and counseling, molecular diagnostics, and cancer clinical trials through online modules, seminars, team-based learning, and case-based learning activities. The information learned will be used as a platform to describe how molecular changes are detected in the laboratory and leveraged in the clinic for personalized patient care. Students will examine the multidisciplinary teams necessary in the care of cancer patients and the benefits of and challenges that precision medicine offers to oncologists through participation in individualized clinical experiences and tumor boards. Students will also have the ability to pursue their own interests in oncology through student-led presentations on a topic of their choice. [2] Dahlman