Advanced Drug Metabolism

2 credits

Considerations of the enzymology and mechanisms of biotransformation and disposition of drugs and foreign compounds. Includes chemical and biochemical reaction mechanisms, enzyme induction mechanisms, kinetics of inhibition and activation, inter-individual differences in metabolism and bioactivation and toxicity. Prerequisite: MEDCH 529, PCEUT 502, or permission of instructor; recommended: knowledge of chemical and biochemical mechanisms; knowledge of enzyme kinetics; and knowledge of chemical and cellular toxicity. Offered: jointly with PHCOL 527; W.