Bioengineering Thermodynamics

3 units

This course covers the foundations of thermodynamics with strong emphasis on concepts and the translation of concepts. Topics to be covered include the first and second laws of thermodynamics, probabilistic descriptions of entropy, consequences of the first and second laws in ideal and non-ideal single- and multicomponent systems, free energies as descriptors of equilibria in laboratory and biological systems, chemical equilibria, phase equilibria, treatment of aqueous solvents and mixtures, colligative properties, thermodynamics of protein folding, and protein binding equilibria. The material, the lectures, and the homeworks emphasize learning that enables the translation of concepts into mathematical analysis. A strong background in differential calculus of multiple variables and differential equations (Math 217) is required. Emphasis is placed on regular homeworks and working in collaborative groups. The main textbook for the course will be Molecular Driving Forces: Statistical Thermodynamics in Chemistry and Biology, 2nd edition by Ken A. Dill and Sarina Bromberg published by Garland Science. The lectures and course notes will also draw on other sources including the classical book by Herbert Callen. A weekly recitation section will be offered. Students are strongly urged to attend lectures and the recitation section.