Biophysical Chemistry

3 units

This course examines the physical principles that govern the structure, dynamics, functions and organization of biological molecules and systems. We will cover foundational topics such as molecular forces, thermodynamics of folding and binding, phase equilibrium, kinetics of biomolecular reactions, transport phenomena, and the role of water and ions in biological processes. Special emphasis will be placed on experimental techniques—including spectroscopy, calorimetry, microscopy, and molecular simulations—that reveal the physical chemistry of biomolecules and systems. To connect theory with practice, the course will integrate contemporary research drawn from primary literature, highlighting case studies such as protein folding diseases, phase transition, biomolecular condensates, enzyme catalysis, cellular electrochemistry and cellular energetics. Through critical reading and discussion of these works, students will learn how biophysical chemistry informs modern biological research and biotechnological innovation.