The Biology of Membranes

3 units

Biological membranes not only define cell and organelle boundaries but also control the substances that are allowed to enter or exit the cell or organelle. Biomembrane structures, including composition, determine functions. The goal of this class is to examine cell membrane structure, membrane components and their organization into domains, and functions. Cholesterol is an important membrane lipid that is linked to biomembranes structurally and functionally. Misregulation of synthesis or trafficking of lipids, including cholesterol, contributes to many human diseases. Students will learn historical background and recent advances in membrane biology, following the path taken by cholesterol and others.