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BME 587

Special Topics in Biomedical Signals

Undergraduate

Fall 2021 · Topic 13: Optics and Biomedical Optics

Topics

  • Introduction to optics (~ 50%) General overview of the field of optics and photonics: Wave optics, Ray optics, Optical elements, Lasers, LEDs, and optical detectors and devices.
  • Introduction to biomedical optics (~10%- 20%) General behavior of light in biological tissue, Physics of light-matter interaction, Absorption and its biological origins, Scattering and its biological origins, Polarization and its biological origins, Fluorescence and its biological origins.
  • Sensing of optical properties and spectroscopy (~10%) Spectrophotometry, Oblique-incidence reflectometry, White-light spectroscopy, Time- resolved measurement, Fluorescence spectroscopy. The application of spectroscopy techniques in the field of biomedical engineering will be discussed.
  • Optical imaging and microscopy (~10%- 20%) Motivation for optical imaging, Characteristics of ballistic light, Time-gated imaging, Polarization difference imaging, Confocal microscopy, Two-photon microscopy, Optical coherence tomography, Photoacoustic imaging, and holography. Clinical and pre-clinical applications of microscopy techniques will also be discussed.
  • Applications of biomedical optics (If time permits- Preferred topics for the project) New and exciting optical devices/applications will be covered such as wearable devices, surgical devices, endoscopic devices, 3D glasses, Photomedicine applications, and optical tweezers.

Readings

  • Lihong V. Wang, Hsin -I Wu: Biomedical Optics: Principles and Imaging, Publisher: Wiley
    unspecified
  • Identify design possibilities offered by biomedical optics (2)
    unspecified
Sources