Structural Proteomics and Its Applications

Graduate

This course provides an introductory overview of the technologies and practices in structural proteomics and its applications. It will cover the history, current status, and the workflow of high-throughput approaches to structural biology. It will introduce the concepts of drugability, target selection and validation, chemical probes, chemogenomics in modern drug discovery and the critical role of structural proteomics in these applications. Also, progress in several important protein families, such as kinase, methyltransferase, deubiquitinase, will be discussed. This course is intended for graduate students in life science major who have interests in protein structural biology, want to interface with structural biologists or utilize the knowledge in their study and research. (2 lecture hours/week.) (May be offered as a cross- career course with BIOC-4008)