PROTEIN AND ENZYME STRUCTURE AND FUNCTION

Prerequisites & course information

Requisites: CHEM 345 and ( BIOCHEM 501 or 507 ) or graduate/professional standing Course Designation: Core GenEd - Natural Science & Wellness + Lab Breadth - Physical Science Level - Advanced L&S Credit - L&S Liberal Arts and Science Grad 50% - Counts toward 50% graduate coursework requirement Repeatable for Credit: No Last Taught: Fall 2026 Learning Outcomes: 1. Identify basic stereochemical principles of protein components Audience: Both Grad & Undergrad 2. Describe the chemistry of amino acids Audience: Both Grad & Undergrad 3. Describe the noncovalent forces that control the secondary and tertiary structure of proteins Audience: Both Grad & Undergrad 4. Evaluate the fundamental strengths and weaknesses of structures determined by X- ray crystallography and electron microscopy Audience: Both Grad & Undergrad 5. Explain chemical kinetics as they apply to enzymes Audience: Both Grad & Undergrad 6. Differentiate the role of cofactors in enzyme chemistry Audience: Both Grad & Undergrad 7. Explain the fundamental underpinnings of protein stability, protein evolution, and their application to protein engineering by site-directed mutagenesis Audience: Both Grad & Undergrad 8. Distinguish the key features of representative enzymes families including the ATPases and the peptidases Audience: Both Grad & Undergrad 9. Compare the differences and unique properties of membrane proteins Audience: Both Grad & Undergrad 10. Critically evaluate the primary biochemical literature regarding protein structure, function, and enzyme catalysis Audience: Graduate Learning Outcomes: 1. Identify basic stereochemical principles of protein components Audience: Both Grad & Undergrad 2. Describe the chemistry of amino acids Audience: Both Grad & Undergrad 3. Describe the noncovalent forces that control the secondary and tertiary structure of proteins Audience: Both Grad & Undergrad 4. Evaluate the fundamental strengths and weaknesses of structures determined by X- ray crystallography and electron microscopy Audience: Both Grad & Undergrad 5. Explain chemical kinetics as they apply to enzymes Audience: Both Grad & Undergrad 6. Differentiate the role of cofactors in enzyme chemistry Audience: Both Grad & Undergrad 7. Explain the fundamental underpinnings of protein stability, protein evolution, and their application to protein engineering by site-directed mutagenesis Audience: Both Grad & Undergrad 8. Distinguish the key features of representative enzymes families including the ATPases and the peptidases Audience: Both Grad & Undergrad 9. Compare the differences and unique properties of membrane proteins Audience: Both Grad & Undergrad 10. Critically evaluate the primary biochemical literature regarding protein structure, function, and enzyme catalysis Audience: Graduate