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MEDICINE 905

THE APPLIED PHYSIOLOGY OF MECHANICAL VENTILATION

2 credits.

Focus on the intersection between the physiology of the respiratory system and the mechanical engineering of ventilators, with particular attention to patient-ventilator interactions. Investigate the important physiologic trade-offs inherent in various strategies of mechanical ventilation. Apply these principles to patients with and without underlying pulmonary disease. Finally, evaluate a landmark study on tidal volume in ARDS, with particular attention to the scientific and ethical controversies that surround the trial. This course involves a modicum of physics and math.

Prerequisites & course information

Requisites: MED SC-M 810 , 811 , 812 , and 813 Course Designation: Grad 50% - Counts toward 50% graduate coursework requirement Repeatable for Credit: No Last Taught: Fall 2026 Learning Outcomes: 1. Demonstrate knowledge of respiratory system physiology and mechanics Audience: Graduate 2. Demonstrate familiarity with how ventilators have been engineered Audience: Graduate 3. Compare and contrast how patients and ventilators interact with each other in a variety of modes of mechanical ventilation and in a variety of disease states Audience: Graduate 4. Apply understanding of mechanical ventilation to appraise lessons from ARDSNet trial Audience: Graduate 5. Describe ethical and scientific challenges in establishing an appropriate control group for a clinical trial Audience: Graduate Learning Outcomes: 1. Demonstrate knowledge of respiratory system physiology and mechanics Audience: Graduate 2. Demonstrate familiarity with how ventilators have been engineered Audience: Graduate 3. Compare and contrast how patients and ventilators interact with each other in a variety of modes of mechanical ventilation and in a variety of disease states Audience: Graduate 4. Apply understanding of mechanical ventilation to appraise lessons from ARDSNet trial Audience: Graduate 5. Describe ethical and scientific challenges in establishing an appropriate control group for a clinical trial Audience: Graduate

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