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NUTR SCI 645

MOLECULAR CONTROL OF METABOLISM AND METABOLIC DISEASE

3 credits.

Examination of various physiological states and how they affect metabolic pathways. Discussion of a number of special topics related to the unique roles of various tissues and to metabolic pathways in disease states, including adipocyte biology, beta-cell biology, epigenetics, inflammation, and aging related diseases.

Prerequisites & course information

Requisites: BIOCHEM 501 , 508 or graduate/professional standing Course Designation: Core GenEd - Natural Science & Wellness + Lab Breadth - Biological Science Level - Advanced L&S Credit - L&S Liberal Arts and Science Repeatable for Credit: No Last Taught: Fall 2026 Learning Outcomes: 1. Identify the mechanisms by which tissues maintain metabolic flexibility. Audience: Undergraduate 2. Differentiate between how lipid metabolism regulates carbohydrate metabolism and vice versa. Audience: Undergraduate 3. Describe the regulation of lipogenesis. Audience: Undergraduate 4. Discuss how hormone secreting endocrine cells in the pancreas sense nutrients to regulate blood glucose. Audience: Undergraduate 5. Explain the importance of intracellular lipid cycling for body temperature regulation. Audience: Undergraduate 6. Discuss the manner in which mitochondrial metabolism is assessed. Audience: Undergraduate 7. Examine hormonal regulation of circadian rhythms. Audience: Undergraduate 8. Describe the basis for thermogenesis. Audience: Undergraduate 9. Explain the pathways leading to inflammation. Audience: Undergraduate Learning Outcomes: 1. Identify the mechanisms by which tissues maintain metabolic flexibility. Audience: Undergraduate 2. Differentiate between how lipid metabolism regulates carbohydrate metabolism and vice versa. Audience: Undergraduate 3. Describe the regulation of lipogenesis. Audience: Undergraduate 4. Discuss how hormone secreting endocrine cells in the pancreas sense nutrients to regulate blood glucose. Audience: Undergraduate 5. Explain the importance of intracellular lipid cycling for body temperature regulation. Audience: Undergraduate 6. Discuss the manner in which mitochondrial metabolism is assessed. Audience: Undergraduate 7. Examine hormonal regulation of circadian rhythms. Audience: Undergraduate 8. Describe the basis for thermogenesis. Audience: Undergraduate 9. Explain the pathways leading to inflammation. Audience: Undergraduate

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