Mitochondrial Bioenergetics and Intermediary Metabolism

Graduate / Professional

A comprehensive introduction to the fundamentals of mitochondrial physiology and pathophysiology. Topics include glucose, lipid, amino acid, and cholesterol metabolism; mitochondrial bioenergetics; flux modeling; inherited and acquired metabolic disorders; and common methods used to characterize metabolism. Our goal is for students not only to be able to explain the key pathways involved in maintenance of glucose and lipid homeostasis, but also to be able to select and critically evaluate techniques commonly used in metabolism, design experiments, and interpret others’ results. The class is conducted in a semi-flipped manner: portions of lectures are recorded and posted in advance, and most meetings are a mix of lecture and an activity (discussion, exercise, or quiz). Open to all Yale graduate students and to undergraduates who have taken at least one term of biochemistry. Undergraduates must contact Dr. Perry in advance about their interest in the course. HTBA