CHEM 125a
Freshman Organic Chemistry I
Fall 2008
Topics
- How Do You Know?
- Force Laws, Lewis Structures and Resonance
- Double Minima, Earnshaw's Theorem and Plum-Puddings
- Coping with Smallness and Scanning Probe Microscopy
- X-Ray Diffraction
- Seeing Bonds by Electron Difference Density
- Quantum Mechanical Kinetic Energy
- One-Dimensional Wave Functions
- Chladni Figures and One-Electron Atoms
- Reality and the Orbital Approximation
- Midterm Exam 1
- Orbital Correction and Plum-Pudding Molecules
- Overlap and Atom-Pair Bonds
- Overlap and Energy-Match
- Checking Hybridization Theory with XH3
- Chemical Reactivity: SOMO, HOMO, and LUMO
- Recognizing Functional Groups
- Reaction Analogies and Carbonyl Reactivity
- Amide, Carboxylic Acid and Alkyl Lithium
- Oxygen and the Chemical Revolution (Beginning to 1789)
- Midterm Exam 2
- Rise of the Atomic Theory (1790-1805)
- Berzelius to Liebig and Wöhler (1805-1832)
- Radical and Type Theories (1832-1850)
- Valence Theory and Constitutional Structure (1858)
- Determining Chemical Structure by Isomer Counting (1869)
- Models in 3D Space (1869-1877); Optical Isomers
- Van't Hoff's Tetrahedral Carbon and Chirality
- Communicating Molecular Structure in Diagrams and Words
- Stereochemical Nomenclature; Racemization and Resolution
- Preparing Single Enantiomers and the Mechanism of Optical Rotation
- Midterm Exam 3
- Esomeprazole as an Example of Drug Testing and Usage
- Preparing Single Enantiomers and Conformational Energy
- Stereotopicity and Baeyer Strain Theory
- Conformational Energy and Molecular Mechanics
- Sharpless Oxidation Catalysts and the Conformation of Cycloalkanes
- Understanding Molecular Structure and Energy through Standard Bonds
- Bond Energies, the Boltzmann Factor and Entropy
- Potential Energy Surfaces, Transition State Theory and Reaction Mechanism
- Final Exam
Readings
- Reading assignments, problem sets, PowerPoint presentations, and other resources for this course can be accessed from Professor McBride's on-campus course website, which was developed for his Fall 2008 students. Please see Resources section for each individual lecture.
Sources
- Course catalogue ↗Historical Open Yale Courses
- Historical Open Yale Courses offering. Texts and lecture titles are reproduced as bibliographic and topic information; reading requirements vary by the linked syllabus.