Macromolecular Structure and Biophysical Analysis

Graduate / Professional

This course provides an in-depth analysis of macromolecular structure through the integrated application of structural biology, spectroscopy, and biochemistry. It emphasizes how these complementary approaches collectively advance our understanding of molecular structure and function. Topics include the structural organization of proteins, RNA, and DNA; practical strategies for structural determination; and an introduction to key techniques such as x-ray diffraction, cryo-electron microscopy (cryo-EM), and AI-based structure prediction. Prerequisites: physical chemistry (may be taken concurrently) and biochemistry. TTh 11:35am-12:50pm